Kawasaki disease (KD) is an acute febrile systemic vasculitis, and the cause of KD is not well understood. It is likely due to multiple interactions between genes

ITPKC gene expression in Bgee. Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them.

Bgee i: ENSG00000086544, Expressed in lower esophagus mucosa and 209 other tissues Itpkc MGI Mouse Gene Detail - MGI:2442554 - inositol 1,4,5-trisphosphate 3-kinase C. View mouse Itpkc Chr7:27207170-27228617 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home. Inositol 1,4,5-trisphosphate 3-kinase (ITPK) catalyzes the phosphorylation of Ins (1,4,5)P3 to Ins (1,3,4,5)P4, both of which are modulators of calcium homeostasis. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and inositol tetrakisphosphate 1-kinase activity.

Itpkc gene

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. Human Gene ITPKC (ENST00000263370.3) Description and Page Index Description: Homo sapiens inositol-trisphosphate 3-kinase C (ITPKC), mRNA. (from RefSeq NM_025194) Panel Description This is a next generation sequencing (NGS) test appropriate for individuals with clinical signs and symptoms, suspicion of, or family history of Kawasaki Disease. Sequence variants and/or copy number variants (deletions/duplications) within the ITPKC gene will be detected with >99% sensitivity. Inositol 1,4,5-trisphosphate 3-kinase (ITPK) catalyzes the phosphorylation of Ins (1,4,5)P3 to Ins (1,3,4,5)P4, both of which are modulators of calcium homeostasis. We previously identified 2 susceptibility genes for KD, inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) on 19q13.2 and caspase-3 (CASP3) on 4q34-35 through a genome-wide sib-pair study, followed by The ITPKC gene provides instructions for making an enzyme called inositol 1,4,5-trisphosphate 3-kinase C. This enzyme helps limit the activity of immune system cells called T cells .

Genetic polymorphisms of the ITPKC gene, which encodes the InsP3 3-kinase C protein that inactivates InsP3 (Figure 2), have been linked to an increased risk Keywords: Gene Expression, Hub Genes, RT-PCR, ROC Curve, WGCNA 1,4,5 -trisphosphate 3-kinase C (ITPKC) gene has been associated with enhanced in the ITPKC gene in that region was associated with an increased KD susceptibility and with subsequent development of coronary artery le- sions [23].

Genetic polymorphisms of the ITPKC gene, which encodes the InsP3 3-kinase C protein that inactivates InsP3 (Figure 2), have been linked to an increased risk

ITPKC Acronym for "Inositol trisphosphate 3-kinase C" is a protein coding gene located on chromosome 19q13.2. The ITPKC gene encodes as one of three isoenzymes (ITPKA and ITPKB) for a member of the inositol 1,4,5-trisphosphate 3-kinase family.

sm was conducted on 280 unrelated Taiwanese children with KD and 492 healthy ethnically and gender-matched controls. The clinical manifestations and laboratory data were systemically collected. Results: The GC and CC genotypes of ITPKC gene SNP rs28493229 were overrepresented in KD patients (GG:GC:CC was 236:43:1, C allele frequency: 8.04%) than those in the controls (GG:GC:CC was … 2019-12-07 ITPKC Antibodies Inositol 1, 4, 5-trisphosphate 3-kinase (ITPK) catalyzes the phosphorylation of Ins(1, 4, 5)P3 to Ins(1, 3, 4, 5)P4, both of which are modulators of calcium homeostasis. ITPK isoforms include ITPKA, ITPKB, and ITPKC, all of which contain a conserved catalytic unit in their C termini, but have unique N-terminal sequences and tissue distributions. This gene plays a role in both second messenger metabolism and calcium homeostasis. Skip to search form Skip to main content > Semantic Scholar's Logo.

If you continue, we'll … ITPKC gene expression in Bgee. Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them. The gene view histogram is a graphical view of mutations across ITPKC. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Gene. ITPKC.
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This gene that has been associated with Kawasaki disease . [1] Kawasaki disease is an acute febrile illness that involves the inflammation of blood vessels throughout the body. The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins (1,4,5)P3 to produce a molecule called Ins (1,3,4,5)P4.

Kawasaki disease is an acute febrile illness that involves the inflammation of blood vessels throughout the body. ITPKC (Inositol-Trisphosphate 3-Kinase C) is a Protein Coding gene. Diseases associated with ITPKC include Kawasaki Disease and Coronary Aneurysm.
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Grafting data. Select colouring. Color cells by. Cell origin, Cluster Katarina, Cluster Seurat, Gene Expression. Select gene: Start_typing, DDX11L1:

We investigated the association between calcium containing nephrolithiasis and genetic variants of ITPKC gene in Taiwanese patients. 365 patients were recruited in this study. ITPKC.

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General information; Gene symbol: ITPKC: Gene name: inositol-trisphosphate 3-kinase C: Chromosome: 19: Chromosomal band: q13.1: Imprinted: Unknown: Genomic reference

Directed by Professor Ho-Seong Kim. Keywords: Gene Expression, Hub Genes, RT-PCR, ROC Curve, WGCNA 1,4,5 -trisphosphate 3-kinase C (ITPKC) gene has been associated with enhanced 30 Nov 2018 As such, ITPKC, an upstream regulator of SOC entry, is a potential candidate gene for osteoclastogenesis as well.